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Keep track of Closely (three)pentobarbital will decrease the level or effect of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Solid or moderate CYP3A4 inducers may well enhance rate of diazepam elimination; thus, efficacy of diazepam could be decreased.pentobarbital will decrease the level or impac